2,4- and 2,5-substituted pyridine-N-oxides, processes for their

Details 2,4- and 2,5-substituted pyridine-N-oxides, processes for their 2,4- and 2,5-substituted pyridine-N-oxides, processes for their

1992-11-19

1993-11-09

Richter, Johann

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514332, 514333, 514334, 514354, 514355, 514318, 546256, 546257, 546262, 546263, 546316, 546318, 546321, 546322, 546323, 546326, 546193, 546194, A61K 3144, A61K 31455, C07D21172, C07D21184

Patent

active

052603237

ABSTRACT:
2,4- and 2,5-substituted pyridine-N-oxides are provided which are effective as fibrosuppressives and immunosuppressives. Said compounds are also suitable for the treatment of disorders of the metabolism of collagen and collagen-like substances or the biosynthesis of Clq.

REFERENCES:
Chemical Abstracts, vol. 67, (1967), No. 21, Nov. 20, 1967, No. 98869w,Columbus, Ohio US; Milos Chvapil et al.: "Mechanisms of the anti-fibrous effect of poly-(vinyl-pyridine-N-oxide)": & Prac. Lek. 19(5), 206-11 (1967).
Chemical Abstracts, vol. 97, (1982) No. 25, Dec. 20, 1982, No. 215892f, Columbus, Ohio U.S.; & JP 82109792 (Banyu Pharmaceutical Co. Ltd.) Aug. 7, 1982.
B. Brycki et al., "Kinetics and mechanism of acid hydrolysis of 2-carboethozypyridine N-oxides", Journal of Physical Organic Chemistry, vol. 3, 489-92 (1990).
Kawata et al. Chem. Abstracts, vol. 105, No. 6, 52229n (1986).
Misic-Vukovic et al. Chem. Abstracts, vol. 92, No. 13; 110323q (1980).
Matsumoto et al., Chem. Abstracts, vol. 80, No. 19; 108385v (1974).

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