2,4-and 2,5-bistetrazolylpyridines and the use thereof as pharma

Details 2,4-and 2,5-bistetrazolylpyridines and the use thereof as pharma 2,4-and 2,5-bistetrazolylpyridines and the use thereof as pharma

1994-01-21

1996-01-09

Fan, Jane

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546276, A61K 3144

Patent

active

054829534

ABSTRACT:
The invention relates to 2,4- and 2,5-bistetrazolylpyridines. Said compounds inhibit the enzymes proline hydroxylase and lysine hydroxylase and bring about a selective inhibition of collagen biosynthesis. They are used as fibrosuppressants and immunosuppressants.

REFERENCES:
patent: 4717727 (1988-01-01), Gunzler et al.
patent: 4968670 (1990-11-01), Brocks et al.
patent: 5013736 (1991-05-01), Nagahara et al.
patent: 5037839 (1991-08-01), Bickel et al.
Wade . Organic Chemistry . Prentice-Hall. New Jersey 1987. p. 349.
Suarez et al. Heterocyclic Chem. 15. 1093-1096 1978.
Zeffren et al. The Study of Enzyme Mechanism p. 87. 1974.
Haring, M., et al., Helvetica Chemica Acta, 37(17):147-153 (1954).
Itai, T., et al., Bulletin National Institute of Hygiene, 74:115-117 (1956).
Shinohara, et al., Chemistry High Polymers, Japan, 15:839-849 (1958).
Hirakata, T. et al., J. Pharm. Soc. Japan, 77:219-221 (1957).
Majamaa, K. et al., Eur. J. Biochem, 138:239-245 (1984).
Tschank, G. et al., Biochem. J., 248:625-633 (1987).

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