2,4,6-Trisubstituted-2,3-dihydro-benzofuran derivatives

Details 2,4,6-Trisubstituted-2,3-dihydro-benzofuran derivatives 2,4,6-Trisubstituted-2,3-dihydro-benzofuran derivatives

1978-03-27

1979-03-06

Jiles, Henry R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

26034622, 424285, C07D30779

Patent

active

041430557

ABSTRACT:
New 2,4,6-trisubstituted-2,3-dihydro-benzofuran derivatives of the following general formula ##STR1## wherein R is selected from hydrogen or methyl; one of R.sub.1 and R.sub.2 represents hydroxy, (C.sub.1-4)alkoxy or (C.sub.2-4)alkanoyloxy, and the other one is selected from cyano, carboxy, carbo(C.sub.1-4)alkoxy, carbamoyl and a --NR.sub.3 R.sub.4 group, wherein R.sub.3 and R.sub.4 independently represent hydrogen (C.sub.1-4)alkyl, (C.sub.2-4)alkanoyl, carbo(C.sub.1-4)alkoxy, carbobenzyloxy, carbamoyl, mono- and di-(C.sub.1-4)alkylamino-(C.sub.1-4)alkyl, benzenesulfonyl, toluenesulfonyl, (C.sub.1-4)alkylsulfonyl or phenacylsulfonyl; and salts therewith of pharmaceutically acceptable acids. The compounds have antinflammatory, analgesic and antipyretic utility.

REFERENCES:
wahab et al., J. fur Praktische Chemie, vol. 314 (No. 2), 1972, pp. 213-219.
Royer et al., Bull. Soc. Chim. Fr., (1967) pp. 915-922.
Ramachandran et al., J. of Organic Chemistry, vol. 28, (1963) pp. 398-403.
Epstein et al., J. of Organic Chemistry, vol. 30 (1965) pp. 1246-1247.

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