2,4,6-Triiodobenzonitrile derivatives and X-ray contrast media c

Details 2,4,6-Triiodobenzonitrile derivatives and X-ray contrast media c 2,4,6-Triiodobenzonitrile derivatives and X-ray contrast media c

1979-07-12

1981-05-26

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Molecular bilayer structure

260465D, A61K 4904, C07C12152

Patent

active

042698197

ABSTRACT:
2,4,6-Triiodobenzonitriles of the formula ##STR1## wherein Z is a direct bond or alkylene, X is --COOH or --NR.sub.1 R.sub.2 wherein R.sub.1 is H or hydrocarbon or hydroxy-hydrocarbon and R.sub.2 is lower acyl, and Y is H or --COOH, and their simple esters, amides and pharmaceutically acceptable salts, are useful as X-ray contrast agents and can be prepared by diazotizing the corresponding 2,4,6-triiodoanilines followed by reaction with a metal cyanide.

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