2,4,6-triiodo-1,3-benzenedicarboxylic acid compounds used as rad

Details 2,4,6-triiodo-1,3-benzenedicarboxylic acid compounds used as rad 2,4,6-triiodo-1,3-benzenedicarboxylic acid compounds used as rad

1992-08-27

1995-10-31

Higel, Floyd D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

560 19, 560 42, 560 47, 562433, A61K 4904, A61K 5104, C07C 6314, C07D20740

Patent

active

054630800

ABSTRACT:
Compounds, useful as radiolabeling reagents, including a trihalogenated phenyl ring and having the formula ##STR1## wherein X.sub.1, X.sub.2 and X.sub.3 are halogens, one of which may be a radiohalogen, are disclosed. The invention further includes radiohalogenated proteins as well as processes for preparing such reagents and radiohalogenated proteins.

REFERENCES:
patent: 2611786 (1952-09-01), Wallingford
patent: 3144479 (1964-08-01), Obendorf
patent: 3359278 (1967-12-01), Wallingford
patent: 3476802 (1969-11-01), Holtermann et al.
patent: 3637824 (1972-01-01), Holtermann et al.
patent: 3883578 (1975-05-01), Gries
patent: 4001298 (1977-01-01), Gries et al.
patent: 4001323 (1977-01-01), Felder et al.
patent: 4014986 (1977-03-01), Tilly et al.
patent: 4031088 (1977-06-01), Ackerman
patent: 4321368 (1982-03-01), Hoey
patent: 4735792 (1988-04-01), Srivastava
patent: 4883650 (1989-11-01), Bhargava et al.
patent: 4885153 (1989-12-01), Wilbur et al.
patent: 5047228 (1991-09-01), Gries et al.
patent: 5089249 (1992-02-01), Fritzberg et al.
Eary et al., Antibodies in Radiodiagnosis and Therapy (Ed. Zalutsky), Chapter 5, Radiochemistry of Halogenated Antibodies, pp. 83-102 (1985).
Keenan et al., Monoclonal Antibiodies in Nuclear Medicine, J. Nucl. Med., 26, pp. 531-537 (1985).
Zalutsky et al., Radiohalogenation of a Monoclonal Antibody Using an N-Succinimidyl 3-(Tri-n-butylstannyl)benzoate Intermediate, Cancer Res., 48, pp. 1446-1450 (1988).
Wilbur et al., III Development of a Stable Radioiodinating Reagent to Label Monoclonal Antibodies for Radiotherapy of Cancer, J. Nucl. Med., 30, pp. 216-226 (1989).
Srivastava et al., Radioiodinated Iodophenyl Maleimide: A Potential Radioimmunoconjugate with Low In Vivo Deiodination, NucCompact, 20, pp. 145-149 (1989).
Stanko et al., Copper Catalysis on Isotopic Exchange as a Novel Approach to Incorporating Iodine and Bromine into Benzene Derivatives, Int. J. Radiat. Appl. Instrum. Part A, 35, pp. 1129-1132 (1984).
Sinn et al., Electrophilic Radioiodine Exchange Labeling in Aqueous Solutions, Int. J. Radiat. Appl. Instrum. Part A, 38, pp. 921-925 (1987).
Wilber, D. S., Radiohalogenation of Proteins: An Overview of Radionuclides, Labeling Methods, and Reagents for Conjugate Labeling, Bioconj. Chem., 3, pp. 433-470 (1992).
Bolton et al., The Labelling of Proteins to High Specific Radioactivities by Conjugation to a .sup.125 I-Containing Acylating Agent. Application to Radioimmunoassay, Biochem. J., 133, pp. 529-539 (1973).

Affiliated with

Also associated with

Rating

2,4,6-triiodo-1,3-benzenedicarboxylic acid compounds used as rad does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 2,4,6-triiodo-1,3-benzenedicarboxylic acid compounds used as rad, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 2,4,6-triiodo-1,3-benzenedicarboxylic acid compounds used as rad will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1773455