Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system
Reexamination Certificate
2003-02-03
2008-05-20
Balasubramanian, Venkataraman (Department: 1624)
Organic compounds -- part of the class 532-570 series
Organic compounds
Four or more ring nitrogens in the bicyclo ring system
C514S245000, C544S197000
Reexamination Certificate
active
07375222
ABSTRACT:
This invention relates to an anti-dementia agent which uses a BEC 1 potassium channel inhibitor as the active ingredient.It was proved that the BEC 1 potassium channel inhibitor has an action to improve learning disorder and is useful as a preventive or therapeutic agent for diseases, preferably dementia, in which the BEC 1 potassium channel is considered to be concerned.Illustratively, it was confirmed by an in vivo test that the BEC 1 potassium channel inhibitor has an action to improve learning disorder.Also, it was found that a compound having 2,4,6-triamino-1,3,5-triazine has a BEC 1 potassium channel inhibitory action.
REFERENCES:
patent: 4742160 (1988-05-01), Dore et al.
patent: 4794135 (1988-12-01), Wheeler et al.
patent: 5498701 (1996-03-01), Pedrazzi
patent: 5744127 (1998-04-01), Giuseppe et al.
patent: 5922122 (1999-07-01), Takeda et al.
patent: 6117996 (2000-09-01), Lowe et al.
patent: 6123763 (2000-09-01), Kamikubo et al.
patent: 6150360 (2000-11-01), Daeyaert et al.
patent: 6193960 (2001-02-01), Metzger et al.
patent: 6262053 (2001-07-01), Uckun et al.
patent: 6326168 (2001-12-01), Miyake et al.
patent: 6335339 (2002-01-01), Arenas et al.
patent: 1 050 542 (2000-08-01), None
patent: 951667 (1964-03-01), None
patent: 48008916 (1973-02-01), None
patent: 61246261 (1986-11-01), None
patent: 11-43448 (1999-02-01), None
patent: 11158073 (1999-06-01), None
patent: 11199796 (1999-07-01), None
patent: WO 99/01442 (1999-01-01), None
patent: 9936410 (1999-07-01), None
patent: WO 99/50256 (1999-10-01), None
patent: WO 00/69823 (2000-11-01), None
patent: WO 00/78738 (2000-12-01), None
patent: WO 01/02406 (2001-01-01), None
patent: WO 01/22938 (2001-04-01), None
patent: WO 01/66743 (2001-09-01), None
patent: WO 03/024448 (2003-03-01), None
patent: WO 03/024926 (2003-03-01), None
Donald W. Ludovici et al., “Evolution of Anti-HIV Drug Candidates Part 2: Diaryltriazine (DATA) Analogues” (2001), Bioorganic Y Medicinal Chemistry Letters, pp. 2230-2234.
A.C. Chawda et al., “Preparation and Antimicrobial Activity of 2, 4-Diarylamino-6-({acute over (α)}-Phenyl Sulphonyl) Benzylamino-S-Triazines” (1992), Acta Ciencia Indicia, vol. XVIII C, No.4, pp. 405-406.
P.M. Parasharya et al., “Studies on s-Triazoines: Part-XIV Preparation and Antimicrobial Activity of 2,4-Diarylamino 6-Dimethylaminoethyl-Amino s-Triazines” (1985), Acta Ciencia Indicia, vol. XI c, No.1, pp. 66-69.
W. Brandes et al., “Studies on 1,3,4-Oxadiazoles, Part-IV. Preparation of 2-Ary 1-5-(2,4-bis-P-chlorophenyl-amino-s-triazin-6-ylaminomethyl)-1,3,4-oxadiazoles” (1987), J. Indian Chem. Soc., vol. LXIV, pp. 770-771.
Lina Mehta et al., “Studies on S-Triazines Part-I: Preparation of 2,4-Diarylamino-6-N,N-Diethylaminoethylamino/N,N-Diethylamino Ethoxy-S-Triazines” (1987), J. Inst. Chemists (India), vol. 59, pp. 183-185.
K.R. Desai et al., “Synthesis of s-Triazline Derivatives” (1988), J. Indian Chem. Soc., vol. LXV, pp. 300-301.
International Search Report dated May 6, 2003.
Akira Miyake et al., “New Ether-a-go-go K+Channel Family Members Localized in Human Telencephalon”, (1999) The Journal of Biological Chemistry, vol. 274, No. 35, pp. 25018-25025.
“Potassium Channels and Chloride Channels” (1992) Ionic Channels of Excitable Membranes, Second Edition.
“Potassium Channels” (2002), IUPHAR, pp. 59-63.
Shun-ichi Yamaguchi et al., “Effects of anticonvulsant drugs on 4-aminopyridine-induced seizures in mice” (1992), Elsevier Science Publishers B.V., pp. 9-16.
M. Gwilt et al., “UK-68,798: A Novel, Potent and Highly Selective Class III Antiarrhythmic Agent Which Blocks Potassium Channels in Cardiac Cells” (1990), The Journal of Pharmacology and Experimental Therapeutics, vol. 256, No. 1, pp. 318-321.
Irwin B. Levitan et al., “Cell and Molecular Biology” (1991), Oxford University Press, pp. 395-423.
Sushmita, Ganguly S. et al., “s-Triazines-Part - I: 2, 4 - BIS - (2′Acetyl - Phenylamino)-6-Arylamino/Substituted Amino-s-Triazines”, J. Inst. Chemists, 1996, Part 1, p. 17-18, vol. 68, Part I, Chemistry Department, Saurashtra University, India.
Desai, K.R. et al., “Synthesis and Antibacterial Activity of 2,4-BIS (4-Methoxy Anilino) -6-(N-Aryl thioureido-N′-Amino Acyl)-s-Triazine Derivatives”, J. Inst. Chemists, Jan. 1989, pp. 19-20, vol. 61, Department of Chemistry, South Gujarat University, India.
Pandya, U.H. et al., “Studies on Cyanuric Cholride Derivatives Part-(III)”, J. Inst. Chemists, Mar. 1981, pp. 83-84, vol. 53, University Department of Chemistry, Bhavnagar University, Bhavnagar, India.
Pandya, U.H. et al., “Studies on Cyanuric Chloride Derivatives Part (II)”, J. Inst. Chemists, Mar. 1981, pp. 81-82, vol. 53, University Department of Chemistry, Bhavnagar University, Bhavnagar, India.
Rajnani, H.B. et al., “Studies on Thioureas-Part-I: Preparation and Antibacterial Activityof 2,4-Diarylamino-s-Triazin-6-yl-Aminoacyl Phenylthioureas”, J. Inst. Chemists, Jul. 1977, pp. 222-224, vol. 49, No. 4, University Department of Chemistry, Saurashira University, Bhavnagar, India.
Acharya, J.N. et al., “Studies on s-Triazinyl Compounds as Potential Medicinal Agents. Part II”, J. Indian Chemical Society, Feb. 1976, pp. 193-195, vol. 53, University Department of Chemistry, Saurashtra University, Bhavnagar, India.
Labrecque, G.C. et al., “Substituted Melamines as Chemosterilants of House flies”, Journal of Economic Entomology, Eschile and Miller: Control of Horn Flies, Dec. 1968, pp. 1621-1632, vol. 61, No. 6, Entomology Research Division, Agr. Res. Serv., USDA.
D'Alelio, G.F. et al., “Prepraration of Some Sulfanilamide Derivatives of s-Triazine1”0 Sulfanilamide Derivatives of s-Triazines, J. Organic Chemistry, May 1959, pp. 643-644, vol. 24, Department of Chemistry, University of Notre Dame.
Ashley, J.N., et al. “The Search for Chemotherapeutic Amidines. Part XVI. Amidinoanilino-1,3,5-triazines and Related Compounds”, J. of the Chemical Society, 1960, pp. 4525-4532.
Campbell, J. Robert et al., “Unsymmetrically Substituted Melamines”, J. of Organic Chemistry, Aug. 1961, pp. 2786-2789, vol. 26, The Organic Chemicals Division, Research Department, Monsanto Chemical Co.
Desai, Vikas A. et al., “2-(4′-Fluoranilino)-4-3(3′-Trifluoromethylanilino)-6-(Arylureido)-s-Triazine As Antibacterials”, J. Inst. Chemicist, Part I, 2000, pp. 35-37, vol. 72, Chemistry Department South Gujarat University, Surat-395007.
Parkekh, Hansa et la., “Optically Active s-Triazine Derivatives Part I-Preparation of D(-)-2, 4-Diarylamino-6-a-Carboxybenzylamino-s-Triazines” J. Inst. Chemists, Mar. 1975, p. 63-65, vol. XLVII, University Department of Chemistry, Saurashtra University, Bhavnagar.
Khatri, Vineeta et al., “Studies in the synthesis of 2,4,6-trichloro-1,3,5-trizine derivatives”, J. Indian Chemical Society, Jan. 2003, pp. 53-54, vol. 80, Department of Chemistry, University of Rajasthan, Jaipur-302 004, India, Department of Chemistry, R.L. Saharia government P.G. College, Kaladera, jaipur-303 801, India.
Desai, P.H. et al., “Preparation of 2,4-(DI 4′Fluoroanilino)-6-(Aryl Thioureido)-s-Triazine and 2-(4′-Fluoroanilino)-4-(Phenyl Thioureido)-6-(Aryl AMINO)-s-Triazine as Antibacterials”, J. Inst. Chemists, Nov. 1989, pp. 207-208, vol. 61, Department of Chemistry, South gujarat University Surat-395 007.
Unishi, Terunobu et al., “Synthesis of 2, 4-Diamino-6, 7-dihydroimidazo[1, 2-a] [1, 3, 5] triazine Derivatives”, The Chemical Society of Japan, 1987, pp. 40-44, vol. 1, Department of Industrial Chemistry, Faculty of Engineering, Fukui University, Bunkyo, Fukui-shi, 910, Japan. (With English Abstract).
Hashimoto, Yoshinori et al., “Thermal Stability of Melamine Derivatives and Its Application for Gas Chromatography”, Kenkyu Hokoku-Asahi Garas
Kubota Hideki
Miura Masanori
Miyake Akira
Mochizuki Shinobu
Nakai Ei-ichi
Astellas Pharma Inc.
Balasubramanian Venkataraman
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