2,4,6-substituted pyridyl derivative compounds useful as...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C546S269400

Reexamination Certificate

active

07968571

ABSTRACT:
The present invention is directed to 2,4,6-substituted pyridyl derivative compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.

REFERENCES:
patent: 4518601 (1985-05-01), Kristiansen et al.
patent: 7109217 (2006-09-01), Coburn et al.
patent: 2006/0058278 (2006-03-01), Coburn et al.
patent: 2006/0149092 (2006-07-01), Nantermet et al.
patent: 2006/0161020 (2006-07-01), Coburn et al.
patent: 2007/0293497 (2007-12-01), Nantermet et al.
patent: WO 03/057721 (2003-07-01), None
patent: WO 03/106405 (2003-12-01), None
patent: WO 2004/022523 (2004-03-01), None
patent: WO 2004/050619 (2004-06-01), None
patent: WO2004/089911 (2004-10-01), None
patent: WO2004/089911 (2004-10-01), None
patent: WO 2005/005374 (2005-01-01), None
patent: WO 2005/018545 (2005-03-01), None
patent: WO 2005/032471 (2005-04-01), None
patent: WO 2005/051914 (2005-06-01), None
patent: WO 2005/065195 (2005-07-01), None
patent: WO 2005/103020 (2005-11-01), None
C. Coburn et al., “Identification of a Small Molecule Nonpeptide Active Site Beta-Secretase Inhibitors . . . ,”, J. Med. Chem., vol. 47, pp. 6117-6119 (2004).
S. Stachel et al., “Structure-Based design of Potent and Selective Cell-Permeable Inhibitors of Human Beta-Secretase (BACE-1),” J. Med. Chem., vol. 47, pp. 6447-6450 (2004).
S. Stachel et al., “Conformationally biased P3 amide replacements of B-secretase inhibitors,” Biorganic & Medicinal Chemistry Letters, vol. 16, pp. 641-644 (2006).
Supplementary European Search Report for PCT/US2005/042087 dated Aug. 18, 2010; 5 pages.
Nantermet, P.; et. al.; “Evolution of Tertiary Carbinamine BACE-1 Inhibitors Aβ Reduction in Rhesus CSF upon Oral Dosing”, ChemMedChem; 2009; 4, pp. 37-40.
Zhu, H.; et. al.; “Rapid P1 SAR of brain penetrant tertiary carbinamine derived BACE inhibitors”, Biiorganic and Medicinal Chemistry Letters, 20 2010 1779-1782.
International Search Report for PCT/US05/013480 filed Apr. 20, 2005 mailed on Jul. 20, 2005; 3 pages.
Written Opinion for PCT/US05/013480 filed Apr. 20, 2005 mailed on Jul. 20, 2005; 4 pages.
International Search Report for PCT/US05/042087 filed Nov. 18, 2005 mailed on Jul. 14, 2006; 3 pages.
Written Opinion for PCT/US05/042087 filed Nov. 18, 2005 mailed on Jul. 14, 2006; 4 pages.
Supplementary European Search Report for PCT/US2005/042087 dated Aug. 18, 2010; 5 pages.

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