2,4,6-substituted phenol derivatives

Details 2,4,6-substituted phenol derivatives 2,4,6-substituted phenol derivatives

1990-08-14

1992-03-03

Chan, Nicky

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514570, 560 17, 560 60, 562431, 562470, 549375, 549292, A61K 3119, A61K 31235, C07C32352

Patent

active

050933639

ABSTRACT:
A 2,4,6-substituted phenol having the formula (I): ##STR1## wherein X is S or CH.sub.2 ; R.sup.1 and R.sup.2 are the same or different from each other and each is a lower alkyl group; R.sup.3 is a group of the formula: ##STR2## in which R.sup.4 is hydrogen atom or a lower alkyl group; R.sup.5 and R.sup.6 are the same or different from each other and each is hydrogen atom, a lower alkyl group, or a phenyl group which may be substituted,
or a pharmaceutically acceptable salt thereof is useful as an active agent in a pharmaceutical composition. The pharmaceutical composition comprises a therapeutically effective amount of a compound having the formula (I), as an effective ingredient, in association with a pharmaceutically acceptable substantially nontoxic carrier or excipient. The pharmaceutical composition can be useful in the treatment of lipemia of mammals. Additionally the compounds can be used as antiatherosclerotic agents and antilipenic agents.

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H. Nakaya, Farumashia, 24, 1217, (1988).
Probucol, The Merck Index, 11th Ed., pp. 1230, 7761.

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