2,4,5 Trifluoro pyrimidine and process for preparing

Details 2,4,5 Trifluoro pyrimidine and process for preparing 2,4,5 Trifluoro pyrimidine and process for preparing

1980-01-07

1981-11-10

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544313, C07D23924

Patent

active

042999618

ABSTRACT:
A process for preparing 5-fluorouracil, and a novel starting compound for such process, are disclosed. The novel starting compound is 2,4,5-trifluoropyrimidine. The process comprises hydrolyzing the 2,4,5-trifluoropyrimidine at a temperature of about 2.degree. to about 100.degree. C., thereby directly producing the compound 5-fluorouracil.
5-fluorouracil is a known anti-tumor agent, which has been used in the treatment of various types of cancers. In addition, 5-fluorouracil is a starting material for the production of certain types of pro-drugs, which are metabolized to form 5-fluorouracil in the body, such as, for instance, the compound 1-(2-tetrahydrofuryl)-5-fluorouracil.

REFERENCES:
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patent: 3485839 (1969-12-01), Fuller
patent: 3694444 (1972-09-01), Klauke et al.
patent: 4140857 (1979-02-01), Beck et al.
patent: 4171442 (1979-10-01), Beck et al.

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