Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2011-06-07
2011-06-07
Loewe, Sun Jae Y. (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C548S235000
Reexamination Certificate
active
07956077
ABSTRACT:
The present invention comprises compounds and compositions for the treatment of metabolic disorders and more particularly, those insulin-related metabolic disorders of the blood such as hyperlipidemia, diabetes, insulin-resistence and the like comprising acetic acid derivatives with cyclohexylmethoxy substituents and their salts. Known as peroxisome proliferator-activated receptors (PPAR) agonists/antagonists, the invention relates to compounds of formula Iwherein the various substituent R-groups are more specifically defined herein.
REFERENCES:
patent: 7259177 (2007-08-01), Stapper et al.
patent: 7335671 (2008-02-01), Stapper et al.
patent: 2008/0015238 (2008-01-01), Stapper et al.
patent: WO 03/020269 (2003-03-01), None
patent: WO 2004/076427 (2004-09-01), None
http://www.fda.gov/cder/present/DIA2006/EI-Hage—Safety.pdf.
Zips et al, “new anticancer agents: in vitro and in vivo”, in vivo, 2005, 19, 1-7.
Megard et al., “A co-culture based model of human blood-brain, barrier: application to active transport of indinavir and in vivo-in vitro correlation”, Brain Research, 927, 2002, 153-167.
Fact sheet Alzheimers association, 2 pages.
http://www.mayoclinic.com/health/alzheimers-disease/DS00161/DSECTION=3.
http://www.medindia.net/patients/patientinfo/Alzheimers—treatment.htm.
Hacks Chemical Dictionary, Fourth Edition, Julius Grant, 1972, p. 203.
Newman et al., DDT vol. 8, Oct. 2003, p. 898-90.
Chawla et al., CRIPS vol. 5, No. 1, Jan.-Mar. 2004, p. 9-12.
U.S. Appl. No. 12/013,8, dated Feb. 2004, Stapper et al.
Falk Eugen
Glombik Heiner
Keil Stefanie
Knieps Stephanie
Schaefer Hans-Ludwig
Loewe Sun Jae Y.
Sanofi-Aventis Deutschland GmbH
Scully , Scott, Murphy & Presser, P.C.
LandOfFree
2-{-3,′2-(phenyl)-oxazol-4-ylmethoxyl-cyclohexyl... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 2-{-3,′2-(phenyl)-oxazol-4-ylmethoxyl-cyclohexyl..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 2-{-3,′2-(phenyl)-oxazol-4-ylmethoxyl-cyclohexyl... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2715838