2-(3-Trimethylsilylpropyl)benzothiazole

Details 2-(3-Trimethylsilylpropyl)benzothiazole 2-(3-Trimethylsilylpropyl)benzothiazole

1980-09-11

1982-09-14

Springer, David B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

424184, C07F 710, A61K 31425

Patent

active

043496822

ABSTRACT:
The invention provides a novel compound 2-(3-trimethylsilylpropyl)benzothiazole having remarkable anti-tumor effects or, in particular, inhibiting growth of melanoma cells in test animals. The compound is synthesized by the ring-closing intramolecular dehydration condensation of 2-mercapto-(.gamma.-trimethylsilyl)butyroanilide which in turn is obtained by the dehydrochlorination condensation of 2-aminothiophenol and .gamma.-trimethylsilylbutyryl chloride in a polar solvent in the presence of an acid acceptor.

REFERENCES:
patent: 3008922 (1961-11-01), Lisanke
patent: 3692798 (1972-09-01), Barcza
patent: 3947465 (1976-03-01), Coll
Lankelma et al., J. A.C.S., vol. 58, pp. 609-611, (1936).

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