2,3-trans-disubstituted tropane compounds which have useful phar

Details 2,3-trans-disubstituted tropane compounds which have useful phar 2,3-trans-disubstituted tropane compounds which have useful phar

1993-07-16

1994-12-20

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546124, 546125, 546126, 546132, A61K 3146, C07D45102

Patent

active

053746368

ABSTRACT:
The present invention discloses compounds of the formula ##STR1## any mixture thereof, or a pharmaceutically acceptable salt thereof; wherein R, R.sup.3, and R.sup.4 each have the meanings set forth in the specification.
The compounds possess valuable pharmaceutical properties as dopamine reuptake inhibitors.

REFERENCES:
patent: 3813404 (1974-05-01), Clark et al.
Clark et al., J. Org. Chem. 43(24), pp. 4586-4589, 1978.
Porsolt et al., "Psychotropic screening procedures", Elsevier Science Publishers, Chapter 2, Methods in behavioral pharmacology, ed. F. van Haaren, 1993, pp. 23-51.
J. F. Teste et al., "Anti-immobility activity of different antidepressant drugs using the tail suspension test in normal or reserpinized mice", Fundam. Clin. Pharmacol. 7, 219-226 (1993).
R. L. Clarke et al., J. Med. Chem. 16(11), 1261-1267 (1973).
F. Ivy Carroll et al., J. Med. Chem. 34, 883-883 (1991).
Meltzer et al., J. Med. Chem. 36(7), 855-862 (1993).
F. Ivy Carroll et al., J. Chem. Soc., Chem. Commun., 44-46 (1993).
F. Ivy Carroll et al., Abstracts of 205th ACS meeting, Denver, Colo., Mar. 28-Apr. 2, 1993, item 84 (Feb. 26, 1993).

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