2-(3-Substituted amino-2-hydroxypropoxy)-3-substituted pyrazines

Details 2-(3-Substituted amino-2-hydroxypropoxy)-3-substituted pyrazines 2-(3-Substituted amino-2-hydroxypropoxy)-3-substituted pyrazines

1973-10-19

1976-03-23

Weinberger, Lorraine A.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260243B, 2602471E, 2602472A, 2602472R, 260250BN, 260307F, 260557R, 260558S, 260561S, 260563R, 2605705S, 2605706, 260583EE, 424250, 424248, C07D29500

Patent

active

039460096

ABSTRACT:
2-(3-Substituted amino-2-hydroxypropoxy)-3-substituted pyrazine compounds optionally having substituents in the 5 and/or 6 positions, possessing .beta.-adrenergic blocking properties are described. The products are prepared by reaction of a 2-chloro(or hydroxy)pyrazine with a 5-hydroxy-methyl(or sulfonyloxymethyl)oxazolidine followed by acid hydrolysis.

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