2,3-Polymethylene-4-oxo-4H-pyrido[1,2-a]pyrimidines

Details 2,3-Polymethylene-4-oxo-4H-pyrido[1,2-a]pyrimidines 2,3-Polymethylene-4-oxo-4H-pyrido[1,2-a]pyrimidines

1978-08-18

1980-09-02

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

424251, C07D48714, A61K 31505

Patent

active

042207711

ABSTRACT:
Pharmaceutical intermediates, morphine potentiators and other compounds have the formula ##STR1## wherein R is hydrogen, halogen, C.sub.1-4 alkyl, hydroxy, nitro, amino, carboxy or a carboxylic acid derivate radical, R.sup.1 is hydrogen or a C.sub.1-4 alkyl, R.sup.2 is hydrogen or C.sub.1-4 alkyl, R.sup.3 is hydrogen, R.sup.4 is hydrogen or C.sub.1-4 alkyl, R.sup.5 is hydrogen R.sup.6 is hydrogen or R.sup.3 and R.sup.4 and/or R.sup.5 and R.sup.6 form a chemical bond, X is oxygen or imino, m is 1, 2, 3 or 4, n is 0, 1, 2 or 3, and if n is 1, then the dotted lines can stand for bonds, with the proviso that if m=1 and n=1 and if in the 2,3-, 6,7-, 8,9- and 1,10-positions double bonds are present, and R.sup.1 and R.sup.2 are hydrogen, then R is other than 9-hydroxy or 9-methyl; if m=2 and n=1 and R.sup.2 is hydrogen, then at least one of R and R.sup.1 is other than hydrogen; and if m=2 and n=2 and R.sup.2 is hydrogen and the molecule is a 2,3,4,6,7,8,9,10-octahydro derivative, then at least one of R and R.sup.1 is other than hydrogen or an acid-addition or quaternary salt thereof.

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patent: 3965100 (1976-06-01), Yale
patent: 4033961 (1977-07-01), Schwender et al.
patent: 4083980 (1978-04-01), Schromm et al.
Moehrle, et al., Chemical Abstracts, vol. 80, 14889k (1974).
Devi, et al., Chemical Abstracts, vol. 85, 160393p (1976).
Noda, et al., Chemical Abstracts, vol. 88, 6929y (1978).
Brown, et al., Chemical Abstracts, vol. 75, 48839f (1971).

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