2,3-oxidosqualene-lanosterol cyclase inhibitors

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...

Reexamination Certificate

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C568S306000

Reexamination Certificate

active

06858651

ABSTRACT:
The present invention relates to aminocyclohexanol derivatives useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.

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Auwerx et al., Atherosclerosis XII, pp. 21-39 (2000).
Brown et al., Pyrimidine reactions. XXII. Relative reactivities of corresponding chloro-, bromo-, and iodopyrimidines in aminolysis., J. Chem. Soc. C (1971), 10, 1889-1891.
Karpavichyus et al., Baccat; Bull. Acad.Sci. USSR Div.Chem.Sci (Engl.Transl.);EN;29;1980;1689-1694.
Wermuth, et al., Practise of Medicinal Chemistry, XP002190259, Table 13.1, pp. 203-237 (1996).

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