2,3-Indoledione derivatives

Details 2,3-Indoledione derivatives 2,3-Indoledione derivatives

1980-12-01

1983-07-26

Rollins, Alton D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

424274, 548467, 564214, 564391, 564443, A61K 3140, C07D20938

Patent

active

043955592

ABSTRACT:
2,3-Indoledione derivatives of the formula ##STR1## wherein R is isopropyl or tert.butyl, R.sup.1 is hydrogen or lower alkyl and R.sup.2 is lower alkyl or lower aralkyl, and their pharmaceutically acceptable acid addition salts, prepared from a compound of the formula ##STR2## wherein R.sup.3 is hydroxy and R.sup.4 is chlorine or bromine or R.sup.3 and R.sup.4, taken together, are oxygen, and R.sup.1 and R.sup.2 are as previously set forth, are described. The compounds of formula I and their pharmaceutically acceptable addition salts are useful as .beta.-adrenergic blocking agents and antihypertensive agents.

REFERENCES:
patent: 1778174 (1930-10-01), Thiess et al.
patent: 3825558 (1974-07-01), Seemann
patent: 4137331 (1979-01-01), Berthold et al.
patent: 4212804 (1980-07-01), Coppola

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