2/3-(heterocyclic alkyl amino)-1-(subst.-phenyl-methoxy)-ethanes

Details 2/3-(heterocyclic alkyl amino)-1-(subst.-phenyl-methoxy)-ethanes 2/3-(heterocyclic alkyl amino)-1-(subst.-phenyl-methoxy)-ethanes

1994-11-18

1996-02-27

Haley, Jacqueline

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546176, 546334, 548131, 548252, 548253, 5482632, 5482672, 5483191, 5483195, 5483201, A61K 3142, C07D26310

Patent

active

054949262

ABSTRACT:
Compounds of formula (I), and salts and prodrugs thereof, wherein Q represents phenyl or benzhydryl; X and Y each represent H or X and Y together form a group =0; Z is O, S or NR.sup.8 (R.sup.8 is H or C.sub.1-6 alkyl); R.sup.1 is H, optionally substituted C.sub.1-6 alkyl, phenyl(C.sub.1-4 alkyl), C.sub.2-6 alkylene, COR.sup.a, COOR.sup.a, CONHR.sup.a, COC.sub.1-4 alkylNR.sup.a R.sup.b, or CONR.sup.a C.sub.1-4 alkylCONR.sup.a R.sup.b ; R.sup.2 is C.sub.1-4 alkyl substituted by an optionally substituted aromatic heterocycle; R.sup.3 is H, C.sub.1-6 alkyl or C.sub.2-6 alkenyl; R.sup.4 is H, C.sub.1-6 alkyl or optionally substituted phenyl; R.sup.5 represents optionally substituted phenyl; and q is 0, 1, 2 or 3; are tachykinin antagonists useful in therapy. ##STR1##

REFERENCES:
patent: 5245080 (1993-09-01), Aubard et al.
Curran et al. "The Total Synthesis fo Nocardin A", The Jour. of Antibiotics, vol. XXXV, No. 3 pp. 329-334 1982.
Pascaud et al. "Effects of Fedotozine on Gastrointestinal Motility in Dogs: Mechanism of Action and Related Pharmacokinetics", J. Pharm Pharmacol. 1990, vol. 42, pp. 546-552.
March, J. Advanced Organic Chemistry: Reactions, Mechanisms, and Structure. McGraw-Hill Book Co., New York, 1968.

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