Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1988-12-20
1993-03-02
Lee, Mary C.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
548517, 549548, 514475, A61K 3140, A61K 31335
Patent
active
051909693
ABSTRACT:
The present invention is related to compounds, compositions and methods of treating viral infections. Compounds of the present invention have the following general formula: ##STR1## wherein R is selected from --CH.sub.2 OH, --CO.sub.2 R.sup.2, --CONR.sup.3 R.sup.4, or COR.sup.5, wherein R.sup.2 is hydrogen or a lower alkyl group, R.sup.3 and R.sup.4 are each independently hydrogen or a lower alkyl group, R.sup.5 is an amino acid residue bound via a terminal nitrogen or peptide having at least two amino acid residues; and wherein R.sup.1 is C.sub.5 -C.sub.13 alkyl, aryl, aralkyl, aralkyl(lower alkyl) ether, or C.sub.5 -C.sub.13 alkyl (lower alkyl)ether.
REFERENCES:
patent: 2996521 (1961-08-01), Matthews et al.
Ikuta et al, Virology, 154, pp. 207-213 (1986).
Ikuta et al, Virology, 154, pp. 195-206 (1986).
Katoh et al, Virus Research, 5, pp. 265-276 (1986).
Gao et al, J. Am. Chem. Soc., 109, pp. 5765-5780 (1987).
Omura et al, Antimicrobial Agents and Chemotherapy, vol. 6, No. 2, pp. 207-215 (1974).
Goldfine et al, Biochimica et Biophysica Acta, 512, pp. 229-240 (1978).
Blumenstein Jeffrey J.
Copeland Terry
Michejda Christopher J.
Oroszlan Stephen
Gabilan Mary Susan H.
Lee Mary C.
The United States of America as represented by the Secretary of
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