2,3-epoxy alcohols, acids and derivatives as anti retroviral che

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

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514475, 549548, 549549, 549555, 549560, A61K 31336, A61K 3805, C07D30312, C07K 506

Patent

active

061535893

ABSTRACT:
The present invention is related to compounds, compositions and methods of treating viral infections. Compounds of the present invention have the following general formula: ##STR1## wherein R is selected from --CH.sub.2 OH, --CO.sub.2 R.sup.2, --CONR.sup.3 R.sup.4, or COR.sup.5, wherein R.sup.2 is hydrogen or a lower alkyl group, R.sup.3 and R.sup.4 are each independently hydrogen or a lower alkyl group, R.sup.5 is an amino acid residue bound via a terminal nitrogen or peptide having at least two amino acid residues; and wherein R.sup.1 is C.sub.5 -C.sub.13 alkyl, aryl, aralkyl, aralkyl(lower alkyl)ether, or C.sub.5 -C.sub.13 alkyl(lower alkyl)ether.

REFERENCES:
patent: 2996521 (1961-08-01), Matthews et al.
Pickenahgen et al. Enantioselective Synthesis of Helv. Chim. Acta. vol. 67, pp. 947-952, 1984.
Gao et al. J.A.C.S. (1987) vol. 109 pp. 5765-5780.
PTO Classification Schedule--Class 530 Chemistry: Natural Resins or Derivatives: Peptides or Proteins: Lignins or Reaction Products thereof.
Grant & Hackh's Chemical Dictionary 5th Ed., p. 431.

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