Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1995-02-24
1997-03-11
Gerstl, Robert
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
548240, A61K 3805, G07D26102
Patent
active
056101465
ABSTRACT:
The invention relates to compounds of the formula ##STR1## in which A denotes an optionally substituted radical from the series comprising alkyl, acyl, cycloalkyl, aryl and heteroaryl; A.sup.1 represents CO, CS, C.dbd.NH, CN-alkyl, CN--O-alkyl, SO, optionally substituted CH.sub.2 or a bond; A.sup.2 represents NH, NCH.sub.3, O, CH.sub.2 or a bond; E represents CHOH, CO, SO or optionally N-substituted C.dbd.NH; A.sup.3 represents O, NH, NCH.sub.3 or a bond; R.sup.4 denotes an optionally substituted radical from the series comprising alkyl, cycloalkyl, aryl and heteroaryl; and R.sup.8 denotes hydrogen or optionally substituted alkyl, to a process for their preparation, and to their use as inhibitors of prolyl hydroxylase.
REFERENCES:
V. Gunzler et al., The Journal of Biological Chemistry, vol. 263, No. 36, pp. 19498-19504, 1988.
A. Vessella et al., Chemical Abstracts, vol. 95, No. 7, p. 706, 95:62045p.
A. Vessella et al., Chemical Abstracts, vol. 99, No. 19, p. 654 99:158804u.
Vasella, Helv. Chim. Acta 66 (4) 1241 (1983).
Brocks Dietrich
G unzler Volkmar
Henke Stephan
Gerstl Robert
Hoechst Aktiengesellschaft
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