Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-05-14
1999-10-05
Raymond, Richard L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
544278, 544280, C07D48702, C07D49102, C07D49502, A61K 3138
Patent
active
059624574
ABSTRACT:
The present invention relates to novel compounds of the formula I, described above, and their pharmaceutically acceptable salts, and pharmaceutical compositions and methods of treating neurodegenerative and CNS-trauma related conditions.
REFERENCES:
patent: 3558610 (1971-01-01), Breuer et al.
patent: 5124331 (1992-06-01), Arita et al.
patent: 5252584 (1993-10-01), Carling et al.
patent: 5268378 (1993-12-01), Baker et al.
patent: 5284957 (1994-02-01), Huff
patent: 5426106 (1995-06-01), Kulagowski et al.
patent: 5475008 (1995-12-01), Carling et al.
Chem. Abstract 77:5512t, Jul. 1972.
Damasio, Alzheimer's Disease and Related Dementias, Cecil Textbook of Medicine, 20th Edition, vol. 2, pp. 1992-1996, 1996.
Synthesis of Some New 2-Styryl-3-0-Tolyl-4-Quinazolone as compound of Antifungal Activity; J. Inst. Chemists (India); vol. 60, pp. 58; Mar. 1988; (Miss.) Malti Rawat.
Synthesis of Some Quinazolones; Indian J. Pharm. Sci., 1986, 48(5), pp. 133-136; Jun. 1985; Vijai K. Srivastava, et al.
Synthesis of Heterocyclic Compounds Incorporating 4-Aminostilbene; Indian J. of Chem., vol. 24B, pp. 1039-1042; Oct. 1985; Rajendra S. Varma, et al.
Synthesis and Hypotensive Activity of Trisubstituted Quinazolinones; Eur. J. Med. Chem. Chim. Ther., 1985-20, No. 1, pp. 95-96; A. Kumar, et al.
Synthesis and Antiinflammatory Activity of 2-Substituted-Phenethyl-3-Substituted-Phenyl-4(3H)-Quinazolinones; Indian J. of Chem., vol. 23B, pp. 592-594; Jun. 1984; Inder Pal Singh, et al.
Recent Progress in Excitatory Amino Acid Research; Annual Reports in Medicinal Chem.; Chapter 6, pp. 53-64; 1994; James A. Monn, et al.
Neuronal Cell Death and Strategies for Neuroprotection; Annual Reports in Medicinal Chem.; Chapter 2, pp. 13-22; 1994; Christopher F. Bigge, et al.
Substituierte Chinazolinone-(4) als Hypnotica und Antikonvulsiva; pp. 688-701; Von K.-H. Boltze, et al.
Synthesis of Some 4H-3, 1-Benzoxazin-4-Ones and 4-Quinazolones and Their Reaction with Hydrazines; U.A.R. J. Chem., 14, No. 2, pp. 197-205; 1971; A. Sammour, et al.
Anticonvulsant and Monoamine Oxidase Inhibitory Properties of newer Chlorostrylquinazolones; Pharm. Research Communications, vol. 11, No. 7, pp. 623-633; 1979; R. S. Misra, et al.
Synthesis of Some Quinazolone Derivatives Structurally Related to Certain Sedatives, Hypnotics and Anticonvulsant Agents; Pharmazie 34, H. 11, 1979; A. K. El-Ansary, et al.
Correlation between Monoamine Oxidase Inhibitors and Anticonvulsants; J. of the National Medical Assoc., vol. 72, No. 10, pp. 953-955, 1980; Chundradhar Dwivedi, et al.
Synthesis of Some 4-Substituted Phenylmercaptoacetic Acids; Arch. Pharm. (Weinheim) vol. 314, pp. 97-103, 1981; Rajendra S. Varma, et al.
Synthesis of 2-Styryl-3,6,8-Trisubstituted Qinazolin 4(3H) Ones as Anti-Inflammatory Agents; J. Chem. Soc. Pak.; vol. 3, No. 4, pp. 209-213, 1981; V. S. Misra, et al.
Antimicrobial Activity of 2,3-Disubstituted 4 (3H)-Quinazolone Derivatives; Indian Journal of Forestry; vol. 7(2), pp. 151-153, 1984; S. K. Shukla, et al.
Synthesis of Certain 4 (3H) Quinazolinones likely to Possess CNS Depressant and Antimalarial Activities; Egypt J. Pharm. Sci. vol. 29 No. 1-4, pp. 595-604, 1988; U. L. El Sabagh, et al.
Synthesis and Antifungal Activityof 2-(4-aryl-2-pyrazolin-3-yl)-3-aryl-4-(3H)-Quinazolinones; Indian J. Pharm. Sci., vol. 53 (6), pp. 229-232, 1991; A. Malla Reddy, et al.
Synthesis of Some Quinazolone Derivatives Structurally Related to Certain Sedatives, Hypnotics and Anticonvulant Agents; Dept. of Organic Chemistry; Pharmazie 34, H. vol. 11, 1979; A. K. El-Ansary, et al.
Search for New Anthelmintics Part IV Synthesis of Phenoxy Acid-Salts of Piperazine Containing Quinazolone Moiety; Acta Ciencia Indica; vol. XVI, C, 3, 251, pp. 755-763, 1990; S. S. Tiwari, et al.
4-(3H)-Quinazolones Part II: 2-Alkyl or Arylaminomethyl Substituted Cinnamyl-3-p-(N-Phenylthiouredosulfophenyl)-4-(3H)-Quinazolones; J. Inst. Chemists (India), vol. 63, pp. 66-69, Mar., 1991; V. B. Gaur, et al.
Strucuture activity relationships in the development of excitatory amino acid receptor agonists and competitive antagonists; TiPS; vol. 11, pp. 25-33, 1990; Jeff C. Watkins, et al.
The non-NMDA antagonists, NBQX and GYKI 52466, protect against cortical and striatal cell loss following transient global ischaemia in the rat; Institute of Psychiatry; 571, pp. 115-120, 1992; Eliane Le Peillet, et al.
2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline: A Neuroprotectant for Cerebral Ischemia; Brain Research; vol. 247, pp. 571-574 1990; Malcolm J. Sheardown et al.
Modulation of N-methyl-D-aspartate receptor-mediated increases in cytosolic calcium in cultured rat cerebella granule cells; Brain Research; 552, pp. 13-22, 1991; T. N. Parks, et al.
Delayed AMPA receptor blockade reduces cerebral infarction induced by focal ischemia; NeuroReport; vol. 2, No. 8, pp. 473-476, 1991; Alastair M. Buchan, et al.
(3SR,4aRS,6RS,8 A structurally Novel, Systemically Active, Competitive AMPA Receptor Antagonist; J. Med. Chem.; pp. 2046-2048, 1993; Paul L. Ornstein, et al.
New Developments in the Molecular Pharmacology of .alpha.-Amino-3-hydroxy-5-methyl-4-isoxazole Propionate and Kainate Receptors; Pharmacol. Ther. vol. 70, No. 1, pp. 65-89, 1996; Elizabeth J. Fletcher et al.
ARICEPT.RTM. (Donepezil Hydrochloride tablets); US Product Prescribing Information; pp. 1-20, 1998; Pfizer Inc.
Chenard Bertrand L.
Welch, Jr. Willard M.
Ginsburg Paul H.
Konstas Kristina L.
Pfizer Inc.
Rao Deepak R.
Raymond Richard L.
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