2,3-diketopiperazine derivatives or their salts

Details 2,3-diketopiperazine derivatives or their salts 2,3-diketopiperazine derivatives or their salts

1998-10-29

2000-11-28

Bernhardt, Emily

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

51425214, 5142541, 544295, 544376, 544377, 544379, A61K 31496, A61K 31506, C07D40306, C07D40506, C07D40906

Patent

active

06153613&

ABSTRACT:
The present invention relates to a 2,3-diketopiperazine derivative or a salt thereof, which has inhibitory effect on platelet aggregation because of glycoprotein IIb/IIIa receptor antagonism and hence is useful as a prophylactic and therapeutic agent for diseases associated with platelet aggregation.
General formula ##STR1## wherein R.sup.1 represents a protected or unprotected amidino group; R.sup.2 represents a hydrogen atom or a carboxyl-protecting group; A represents a substituted or unsubstituted lower alkylene group; B represents --O--, --CONH--, --NHCO-- or --SO.sub.2 NH--; Y represents a substituted or unsubstituted lower alkylene group; and the broken line represents a single bond or a double bond.

REFERENCES:
patent: 4948892 (1990-08-01), Tanabe et al.
patent: 5877174 (1999-03-01), Ono et al.
Hori, et al., Chem Pharm Bull. 29, pp. 386-389 (1981).

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