2,3-Dihydro-imidazo[1,2-b]pyridazine derivatives, their preparat

Details 2,3-Dihydro-imidazo[1,2-b]pyridazine derivatives, their preparat 2,3-Dihydro-imidazo[1,2-b]pyridazine derivatives, their preparat

1981-01-15

1982-10-12

Berch, Mark L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544236, 544238, 544224, C07D48704, A61K 3150

Patent

active

043539033

ABSTRACT:
2,3-Dihydro-imidazo[1,2-b]pyridazine derivatives of the formula: ##STR1## in which R.sub.1 represents a phenyl, halogenophenyl, trifluoromethylphenyl, C(.sub.1-4)-alkylphenyl, (C.sub.1-4)-alkoxyphenyl, hydroxyphenyl, nitrophenyl, aminophenyl, (C.sub.1-4)-alkylaminophenyl, di-(C.sub.1-4)-alkylaminophenyl, acetamidophenyl, thienyl, pyridyl, furyl or nitrofuryl radical, R.sub.2 represents a hydrogen atom or a (C.sub.1-4)-alkyl radical, and R.sub.3 represents a hydrogen atom or a (C.sub.1-4)-alkyl, phenyl, halogenophenyl, trifluoromethylphenyl, (C.sub.1-4)-alkylphenyl, (C.sub.1-4)-alkoxyphenyl, hydroxyphenyl, nitrophenyl, aminophenyl, (C.sub.1-4)-alkylaminophenyl, di-(C.sub.1-4)-alkylaminophenyl or acetamidophenyl radical, and its addition salts with pharmaceutically acceptable acids are useful in therapy as antidepressants. They may be made by cyclization of compounds of the formula: ##STR2##

REFERENCES:
patent: 3828041 (1974-08-01), Tomcufcik
Ermoldeva et al., Chem. Abs. 80, 95859a, (1974).
Ostrorasnick et al., Chem Abs. 72, 12684a, (1969).

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