Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1989-09-06
1991-12-10
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
5142305, 544 71, 544 92, C07D26522, C07D26512, C07D49804, A61K 31535
Patent
active
050718509
ABSTRACT:
The invention relates to the new 3-arylalkylaminoalkyl-4H-1,3-benzoxazin-4-one derivatives of general formula ##STR1## in which: R.sub.1, R.sub.2, R.sub.3 and R.sub.4, which may be identical or different, denote a hydrogen, a branched or unbranched lower alkyl group or an alkyloxy, halo, nitro, amino, acylamino or dialkylamino group, and R.sub.1 and R.sub.2 on one hand and R.sub.3, R.sub.4 on the other hand can fuse to give a divalent group and more especially --OCH.sub.2 O--, --OCH.sub.2 CH.sub.2 O-- and --CH.dbd.CH--CH.dbd.CH--; R.sub.5 and R.sub.6, which may be identical or different, denote a hydrogen, a saturated or unsaturated, branched or unbranched alkyl group containing from 1 to 15 carbon atoms or a cycloalkyl group, and R.sub.5 and R.sub.6 can fuse to give a --(CH.sub.2).sub.p -- group with p=2 to 7; R.sub.7 denotes a hydrogen, a saturated or unsaturated, branched or unbranched alkyl group containing from 1 to 15 carbon atoms, a cycloalkyl group, a substituted or unsubstituted aryl and a substituted or unsubstituted arylalkyl; the values of m and n, which may be identical or different, can vary from 1 to 4 inclusive; as well as the therapeutically acceptable organic or inorganic salts of I. The compounds are useful as medicinal products in the treatment of disorders of the cardiovascular system.
REFERENCES:
patent: 2943087 (1960-06-01), Ohnacker et al.
patent: 4341778 (1982-07-01), Mentrup et al.
Grant and Hackh's Chemical Dictionary, 5th ed., 1984, p. 53.
New et al., Chem. Abs., vol. 54 (5), Entry #4818i (1960).
Stamm et al., Chem. Abs. vol. 61 (10), Entry #12012g (1964).
Finkelstein et al., J. Med. Chem., vol. 11, pp. 1038-1040 (1968).
Pierre Fabre Medicament
Shah Mukund J.
Ward E. C.
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