Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-09-22
1999-02-09
Fan, Jane
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C07D40104
Patent
active
058695028
ABSTRACT:
2,3-dihydro-1H-isoindole derivatives of the formula ##STR1## where R.sub.1 -R.sub.5 and X are defined herein which are useful as serotonin reuptake inhibitors are disclosed. As such, these compounds may be useful for the treatment of depression, obsessive-compulsive disorders, stuttering and trichotillomania.
REFERENCES:
patent: 2957872 (1960-10-01), Huebner
patent: 3031458 (1962-04-01), Huebner
patent: 3084167 (1963-04-01), Rice et al.
patent: 3091568 (1963-05-01), Bub et al.
patent: 3322631 (1967-05-01), Sprague et al.
patent: 3849570 (1974-11-01), Raschack et al.
patent: 3875165 (1975-04-01), Archibald et al.
patent: 3947451 (1976-03-01), Jonsson et al.
patent: 4000287 (1976-12-01), Werner et al.
patent: 4038407 (1977-07-01), Eberlein et al.
patent: 4053615 (1977-10-01), Boyle et al.
patent: 4072499 (1978-02-01), Bollinger et al.
patent: 4115398 (1978-09-01), Nakamura
patent: 4124375 (1978-11-01), Bollinger et al.
patent: 4289781 (1981-09-01), Bengsson et al.
patent: 4291042 (1981-09-01), Ward et al.
patent: 4309541 (1982-01-01), Werner et al.
patent: 4724235 (1988-02-01), Shanklin et al.
patent: 4999355 (1991-03-01), Comte et al.
patent: 5026707 (1991-06-01), Nixon et al.
patent: 5053413 (1991-10-01), Desai
patent: 5196434 (1993-03-01), Taverne et al.
patent: 5283263 (1994-02-01), Norden
patent: 5424318 (1995-06-01), Sugomoto et al.
Truitt, et al., New Compounds Vol. 8, 731 (1965).
Suzuki, et al., J. Heterocyclic Chem. 16, p. 645 (1979).
Huffman, J. Heterocyclic Chem. 24, pp. 549-553 (1987).
Hussein, et al., Asian J. of Chemistry, vol. 3, No. 1, p. 30 (1991).
Bornstein, et al., "Organic Syntheses" 406-408.
Bornstein, et al., "Organic Syntheses" 1064-1066.
Bonnett, et al., J, Chem. Soc., Perkin Trans., 1432 (1973).
Kurita et al., Am Chem. Soc., Div. Org. Coat. Plast. Chem. Pop., 33, p. 177 (1973).
CA 109:6377 Moorman et al., (1987).
CA 118:30378, Rodier et al., (1992).
CA 115:49312, Hussein et al., (1991).
CA 115:136387, Hansen et al., (1991).
Whitaker, et al., Annal. of the New York Academy of Science, vol.600, 109-110 (1990).
Principles of Psychopharmacology, Clark et al., Academic Press, NY, 166-167 (1970).
CA 77:5526, Cortrel, et al., (1972).
Chemical Abstracts, vol. 56, No. 1, column 404-g, K. Nakajima (1962).
R.A. Glennon, et al., J. Med. Chem. vol.32, No.8, 1921-1926 (1989).
Kanevskaya, et al., Zh. Obschch Khim. vol.29, pp. 1903-1906 (1957).
Mndzhoyan et al., Izv. Akad. Nauk. Arm.SSR KHIM, Nauki, vol. 15, pp. 95-100 (1962).
Chemical Abstracts, vol. 115, No.5, abstract No. 49312k, Hussein, et al., (1991).
Zee-Cheng, et al., J. Med.Chem. vol. 28, No. 9, pp. 1216-1222, (1985).
Goto et al., CA 114:51261 (1981).
Okazaki et al., CA 109:170232 (1988).
Mohri et al., CA 119:95325 (1993).
Streicher et al., CA 93:204981 (1980).
The Condensed Chemical Dictionary 10th ed. by Hawley, p. 90 (1981).
R.A. Glennon, J. of Medicinal Chemistry, vol.30, No. 1, pp. 1-12 (1987).
CA 84:12490, Carvajal et al., (1976).
Glennon, Journal of Medicinal Chemistry vol. 30, No. 1 pp. 1-12, 1987.
Kapples Kevin James
Shutske Gregory Michael
Fan Jane
Hoechst Marion Roussel Inc.
LandOfFree
2, 3-dihydro-1H-isoindole derivatives and their use as serotonin does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 2, 3-dihydro-1H-isoindole derivatives and their use as serotonin, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 2, 3-dihydro-1H-isoindole derivatives and their use as serotonin will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1948654