Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1988-09-21
1990-01-23
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
5142275, 5142378, 514252, 514253, 514254, 514319, 514357, 514399, 514423, 514428, 514466, 544 59, 544165, 544360, 544372, 544373, 544377, 544383, 544384, 544386, 544387, 544389, 544390, 544391, 544393, 544400, 544401, 544333, 544335, 544366, 544388, 546206, 546337, 548341, 548556, 549430, 549452, A61K 31495, A61K 3144, A61K 31445, C07D29512, C07D29514, C07D29518, C07D21374, C07D23361, C07D20716, C07C 9128, C07C10338, C07C13102
Patent
active
048958476
ABSTRACT:
Novel 2,3-dihydro-1H-indene derivatives and salts thereof represented by the general formula (1), ##STR1## [wherein R.sup.1 and R.sup.2 are each a hydrogen atom, a lower alkyl group, a phenyl group which may have halogen atoms and/or alkyl groups as the substituents on the phenyl ring; R.sup.3 is a halogen atom or a lower alkyl group; R.sup.4 is a hydrogen atom, a halogen atom, a phenyl-lower alkyl group, a cycloalkyl-lower alkyl group or the like; R.sup.5 is a hydroxyimino group, an alkylamino group or a group of the formula --NHR.sup.8 (wherein R.sup.8 is a hydrogen atom, a halogen-substituted lower alkanoyl group or the like); R.sup.6 is a hydrogen atom or a phenyl group; and R.sup.7 is a hydrogen atom or a lower alkyl group].
The 2,3-dihydro-1H-indene derivatives and salt thereof are useful as improving agents for treating anoxemic and hypoxic symptoms and syndromes accompanied therewith, cerebral activators, amnesia curative agents, presbyophrenia curative agents, treating agents for breathing arrest and improving agents for hypoxia accompanied with potassium cyanide poisoning, as well as useful as anti-inflammatory agents and hypotensive agents.
REFERENCES:
Oshiro et al, CA 105-42509q (1986).
Nakagawa Kazuyuki
Oshiro Yasuo
Ueda Hiraki
Otsuka Pharmaceutical Co. Ltd.
Shah Mukund J.
Shen Cecilia
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