2',3'-dideoxy-5-substituted uridines and related compounds as an

Details 2',3'-dideoxy-5-substituted uridines and related compounds as an 2',3'-dideoxy-5-substituted uridines and related compounds as an

1986-05-01

1987-07-21

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 29, C07H 19073

Patent

active

046819339

ABSTRACT:
A compound which exhibits antiviral activity towards HTLV-III/LAV, having the formula: ##STR1## wherein R.sup.4 is O or NH; R.sup.5 is a C.sub.2-4 alkyl group or a C.sub.3-4 cycloalkyl group, wherein said alkyl group or cycloalkyl group may be substituted by one or more of Cl, Br, I, F, OH, N.sub.3, NH.sub.2, SO.sub.3 H, or COOH; R.sup.6 is hydrogen or a C.sub.1 -C.sub.4 alkyl group, which may be substituted by Cl, Br, I, F, OH, N.sub.3, NH.sub.2, SO.sub.3 H, or COOH; R.sup.3' is N.sub.3, NH.sub.2, or H; and R.sup.5' is N.sub.3, NH.sub.2, OH, phosphate, or a C.sub.1-4 acyl group.

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