2',3'-dideoxy-4-thio-uridine derivatives, process for their prep

Details 2',3'-dideoxy-4-thio-uridine derivatives, process for their prep 2',3'-dideoxy-4-thio-uridine derivatives, process for their prep

1988-06-01

1990-09-04

Shen, Cecilia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 43, 514885, 536 23, A61K 31505, A61K 3170, C07D23956

Patent

active

049544853

ABSTRACT:
2',3'-Dideoxy-4-thio-uridine derivatives represented by a following general formula ##STR1## (wherein R indicates hydrogen or protecting groups such as acetyl group, benzoyl group, trityl groups, etc.), process for their preparation, antivirus agents used them as effective ingredients and therapeutic method and therapeutic drugs for virus diseases are disclosed.

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Hobbs et al. Chem. Abst. vol. 78, 1434s, 1973 "Polynucleotides containing 2'-chloro-2'-deoxyribose".
"Potential Anti-AIDS drugs, 2',3'-Dideoxycytidine Analogs".
Rideout et al., Chem. Abst. 107-40276d, (1987), "Therapeutic Necleosdes".
Furukawa et al., Chem. Pharm. Bull. vol. 18(1970) p. 554 "Studies of the Synthesis . . .".

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