Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1989-08-17
1992-10-20
Brown, Johnnie R.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C07H 19073
Patent
active
051571145
ABSTRACT:
The present invention relates to a 3'-substituted pyrimidine nucleoside and its use in medical therapy, particularly in the treatment of HIV infections. Also provided are pharmaceutical formulations.
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Hartman et al., AIDS Research and Human Retroviruses, vol. 4, No. 6, 1988, pp. 457-466, Enhanced In Vitro Inhibition of HIV-1 Replication by 3'-Fluoro-3'-deoxythymidine Compared to Several Other Nucleoside Analogs.
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Balzarini et al., Bio. Chem. Pharm., vol. 37, No. 14, pp. 2847-2856, 1988, Anti-Retrovirus Activity of 3'-Fluoro- and 3'-Azido-Substituted Pyrimidine 2',3'-Dideoxynucleoside Analogues.
Mitsuya et al., "Protection of T Cells Against Infectivity and Cytopathic Effect of HTLV-III In Vitro", part of Retroviruses in Human Lymphoma/Leukemia, Miwa et al., eds., VNU Scienc Press, Utrecht, pp. 277-288, 1985.
Sandstrom et al., "Antiviral Therapy in AIDS," Drugs, vol. 34, pp. 372-390, 1987.
Krenitsky Thomas A.
Rahim Saad G.
Brown Donald
Brown Johnnie R.
Burroughs Wellcome Co.
Crane L. Eric
Nielsen Lawrence A.
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