2',3'-dideoxy-2'-fluoronucleosides

Details 2',3'-dideoxy-2'-fluoronucleosides 2',3'-dideoxy-2'-fluoronucleosides

1992-03-26

1993-06-08

Rollins, John W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 282, 536 286, C07H 1700

Patent

active

052181065

ABSTRACT:
There are disclosed novel 2',3'-dideoxy-2'-fluoronucleosides and 2'-3'-dideoxy-2',3'-didehydro-2'-fluoronucleosides and processes for their preparation. The compounds so produced exhibit therapeutically useful antiviral and, more particularly, anti-HIV effects.

REFERENCES:
Kinney-Thomas et al, Biochemical Pharmacology, vol. 36, No. 3 (1987), pp. 311-316.
DDI Promising in Clinical Trials, Scrip, Jun. 21, 1989, p. 1422.
Mitsuya et al, Proc. Natl. Acad. Sci. USA 83 (1986), pp. 1911-1915.
Chemical Engineering News, Nov. 23, 1987, pp. 44, 45, 48.
Baba et al, Biochem & Biophys. Res. Comm., vol. 142 No. 1, 1987, pp. 128-134.
Yarchoan et al, The Lancet, Jan. 16, 1988, pp. 76-80.
Marquez, et al., Biochem. Pharm. 36(17), 2719-2722, 1987.
Zin, et al., Biochem. Pharm. 36(17): 2713-2718, 1987.

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