2',3'-dideoxy-2'-fluoroarabinopyrimidine nucleosides

Details 2',3'-dideoxy-2'-fluoroarabinopyrimidine nucleosides 2',3'-dideoxy-2'-fluoroarabinopyrimidine nucleosides

1987-11-12

1990-03-13

Rollins, John W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 24, C07H 1900

Patent

active

049084402

ABSTRACT:
There are disclosed novel 2',3'-dideoxy-2'-fluoronucleosides and 2'-3'-dideoxy-2',3'-didehydro-2'-fluoronucleosides and processes for their preparation. The compounds so produced exhibit therapeutically useful antiviral and, more particularly, anti-HIV effects.

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Baba et al., Biochem and Biophys. Res. Comm., 142, No. 1, 1987, pp. 128-134.
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Lin et al, Biochemical Pharmacology, 36, No. 3, pp. 311-316 (1987).
Fauci, Proc. Natl. Aca. Sci., USA, 83, pp. 9278-9283 (1986), Washington Post, Jul. 25, 1988.
Herdewijn et al, The Chemical Abstracts, 107:176403a (1987).

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