Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1992-11-10
1996-10-15
Wilson, James O.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514 46, 514885, 536 267, 536 271, 536 2713, 536 2714, 536 276, 536 278, 536 2781, A61K 3170
Patent
active
055654371
ABSTRACT:
Methods of treating a human infected with human immunodeficiency virus (HIV), such as a human with AIDS, with the purina nucleotides 2',3'-dideoxy-2'-beta-fluoroadenosine (FddA) and 2',3'-dideoxy-2'-beta-fluoroinosine (FddI) are disclosed. These nucleotides are stable in an acid environment and thus can be used for oral administration. Methods of inhibiting human immunodeficiency virus replication in a human T cell using these purina nucleotides are also disclosed.
REFERENCES:
patent: 2928773 (1960-03-01), Klein
patent: 4625020 (1986-11-01), Brundidge et al.
patent: 4666892 (1987-05-01), Fox et al.
patent: 4751221 (1988-06-01), Watanabe et al.
patent: 4788181 (1988-11-01), Driscoll et al.
patent: 4861759 (1989-08-01), Mitsuya et al.
patent: 4880782 (1989-11-01), Eckstein et al.
patent: 4882316 (1989-11-01), Lambert et al.
patent: 4886785 (1989-12-01), Lambert et al.
patent: 4918056 (1990-04-01), Bobek et al.
patent: 4963662 (1990-10-01), Matthes et al.
patent: 4973677 (1990-11-01), Sterzycki et al.
patent: 4997926 (1991-03-01), Haertle et al.
patent: 5126506 (1992-06-01), Sterzycki et al.
patent: 5218106 (1993-06-01), Sterzycki et al.
Alder et al., Antiviral Research, vol. 27, pp. 85-97, (1995).
McCune et al., Annu. Rev. Immunol., vol. 9, pp. 399-429, (1991).
Kaneshima et al., Proc. Natl. Acad. Sci., vol. 88, pp. 4523-4527, (1991).
Watanabe et al., "Synthesis of Antiviral Nucleosides: 5-Alkenyl-1-(2-deoxy-2-fluoro-.beta.-D-arabinofuranosyl) uracils", (1984) J. Med. Chem. 27:91-94.
Cheng et al., "Human Immunodeficiency Virus Reverse Transcriptase-General Properties and Its Interactions With Nucleoside Triphosophate Analogs", (1987), J. Biol. Chem. 262(5):2187-2189.
Lin et al., "Antiviral Activity of 2',3'-Dideoxycytidin-2'-ene (2',3'-Dideoxy-2',3'-Didehydrocytidine) Against Human Immunodeficiency Virus In Vitro", (1987) Biochem. Pharmacol. 36(3):311-316.
Harada et al., "Synthesis and Anticytomegalovirus And Antiherpes Simplex Virus Activity of 5'-Modified Analogues of 2'-Fluoroarabinosyl pyrimidine Nucleosides", (1987) J. Med. Chem. 30:226-229.
Mikhailov et al., "Inhibition Analysis of DNA Replicase (DNA Polymerase .alpha.DNA Primase Complex) And DNA Polymerase of Nuclear Polyhedrosis Virus From Silkworm Cells", (1986) Bioorg. Khim. 12(5):626-632.
Sandstrom et al., Drugs, vol. 38, No. 3, pp. 417-450, 1989.
David P. Hamilton, The Wall Street Journal, Thursday, Aug. 11, 1994. p. B 6.
Mitsuya et al., Retroviruses In Human Lymphomal Leukemia, M. Miwa et al. (EDS) Japan Sci. Soc. Press, pp. 277-288, (1985).
Tann et al., J. Org. Chem. 50:3644-3647 (1985).
Sandstrom et al., Drugs, vol. 34, pp. 372-390 (1987).
Driscoll John S.
Johns David G.
Kelley James A.
Marquez Victor E.
Mitsuya Hiroaki
Benson Robert
Feiler William S.
Morry Mary J.
The United States of America as represented by the Department of
Wilson James O.
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