2',3'-dideoxy-2',3'-didehydro-2'-fluoroarabino-nucleosides

Details 2',3'-dideoxy-2',3'-didehydro-2'-fluoroarabino-nucleosides 2',3'-dideoxy-2',3'-didehydro-2'-fluoroarabino-nucleosides

1989-07-11

1990-11-27

Rollins, John W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 24, C07H 1700

Patent

active

049736779

ABSTRACT:
There are disclosed novel 2',3'-dideoxy-2'-fluoronucleosides and 2'-3'-dideoxy-2',3'-didehydro-2'-fluoronucleosides and processes for their preparation. The compounds so produced exhibit therapeutically useful antiviral and, more particularly, anti-HIV effects.

REFERENCES:
Kinney-Thomas et al., Biochemical Pharmacology, vol. 36 (1987), pp. 311-316.
DDI Promising in Clinical Trails. Scrip. Jun. 21, 1989, p. 1422.
Mitsuya et al., Proc. Natl. Acad. Sci. U.S.A. 83 (1986), pp. 1911-1915.
Chemical Engineering News, Nov. 23, 1987, pp. 44, 45 & 48.
Baba et al. Biochem & Biophys. Res. Comm. 142, No. 1, 1987, pp. 128-134.
Yarchoan et al., The Lancet. Jan. 16, 1988, pp. 76-80.

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