2,3-Dichloro-4-hydroxy-benzoic acid and process for preparation

Details 2,3-Dichloro-4-hydroxy-benzoic acid and process for preparation 2,3-Dichloro-4-hydroxy-benzoic acid and process for preparation

1976-10-04

1978-05-30

Killos, Paul J.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2603322R, C07C 6504

Patent

active

040923525

ABSTRACT:
A Reimer-Tiemann reaction of 2,3-dichlorophenol with carbon tetrachloride gives 2,3-dichloro-4-hydroxy-benzoic acid, a novel intermediate, which is then reacted with thiophene in the presence of phosphorus pentoxide or polyphosphoric acid to give 2,3-dichloro-4-(2-thienoyl)-phenol. This compound is then converted to the diuretic, ticrynafen, by known prior art reactions.

REFERENCES:
patent: 2811547 (1957-10-01), Brown
Chem. Abstr., 77100u, vol. 68, 1968.
Chem. Abstr., 53271y, vol. 74, 1971.

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