2,-3-Di-substituted-5,6-dihydroimidazo [2,1-b] thiazole, its sal

Details 2,-3-Di-substituted-5,6-dihydroimidazo [2,1-b] thiazole, its sal 2,-3-Di-substituted-5,6-dihydroimidazo [2,1-b] thiazole, its sal

1984-04-13

1985-12-03

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548154, C07D51304, A61K 31425

Patent

active

045566690

ABSTRACT:
Compounds of the formula ##STR1## wherein R is ##STR2## in which R.sub.1, R.sub.2 and R.sub.3 are the same or different and are selected from the group consisting of hydrogen, chlorine, bromine, lower alkyl, lower alkoxy and naphthyl, provided that when R.sub.1 is lower alkyl, R.sub.2 and R.sub.3 are hydrogen, chlorine, bromine or lower alkoxy, or a pharmaceutically acceptable salt thereof, have anti-carrageenin edema activity, and are useful as anti-inflammatory agents and immuno modulators. They are produced by reacting an amide of the formula ##STR3## wherein R has the same meanings hereinabove, with N,N'-ethylene thiourea.

REFERENCES:
patent: 4103016 (1978-07-01), Moser
Dhaka et al., Aust. J. Chem. 26, 435, (1970).
Metzger, Thiazoles & Its Derivatives, p. 248, 1979.
Use of N-Bromosuccinimide in the Synthesis of Heterocyclic Systems: by K. S. Dhaka et al., Aust. J. Chem. 1973, vol. 26, pp. 435-436.
Derives de l'Imidazo (2,1-b) Thiazole-III Transposition au Cours de la Condensation d'Acetylacetates d'Ethyle .alpha. et .omega. Halogenes Avec l'Ethylenethiouree: by J. F. Robert et al., "Tetrahedron", vol. 31, pp. 725 to 731.

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