2,3-Di(4-substituted phenyl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidaz

Details 2,3-Di(4-substituted phenyl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidaz 2,3-Di(4-substituted phenyl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidaz

1979-01-08

1980-01-29

Trousof, Natalie

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

548324, A61K 31415, C07D48704

Patent

active

041862058

ABSTRACT:
New 6,7-dihydro-5H-pyrrolo[1,2-a]imidazoles having substituted phenyl groups in the 2- and 3- positions are disclosed. These compounds regulate cell-mediated immunity and/or have anti-arthritic activity and are useful to relieve inflammation, for example in the treatment of rheumatoid arthritis.

REFERENCES:
patent: 3455924 (1969-07-01), Lednicer
patent: 4046898 (1977-09-01), Shaw
Hill et al., Chem. Abst. 1975, vol. 83, No. 130927g.
Kaye et al., J. Amer. Chem. Soc., 1953, vol. 75, pp. 746-748.
Kochergin, Chem. Abst. 1972, vol. 76, No. 25170n.
Okuda et al., J. Amer. Chem. Soc. 1959, vol. 81, pp. 740-743.
Shaw, Chem. Abst. 1976, vol. 85, No. 143109h, (Abstract Ger. Offen. No. 2,603,399).
Hill et al., J. Org. Chem., 1975, vol. 40, pp. 2562-2565.
Kochergin et al., Khim. Geterotskil Soeden 1971, vol. 7, pp. 826-830.

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