2,3-Benzodiazepine Derivatives as non-competitive AMPA

Details 2,3-Benzodiazepine Derivatives as non-competitive AMPA 2,3-Benzodiazepine Derivatives as non-competitive AMPA

1997-04-04

1998-09-15

Sham, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

540567, A01N 4362, C07D24300

Patent

active

058078517

ABSTRACT:
Derivatives of 2,3-benzodiazepine are substituted by one or two halogen atom(s) and have the general formula ##STR1## These derivatives are non-competitive AMPA antagonists and are used in pharmaceutical compositions. A process to make the 2,3-benzodiazepine derivatives includes converting starting compounds which are substituted by one or two halogen groups and have the general formula ##STR2##

REFERENCES:
patent: 5288863 (1994-02-01), Somogyi et al.
Gatta et al., "Derivatives of 2,3-benzodiazepine", IL Farmaco, Vol. XL (Dec. 1985), No. 12, pp. 942-955.

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