2-(3-amino-5-halo-2-pyridylalkylamino)-pyrimidones useful as his

Details 2-(3-amino-5-halo-2-pyridylalkylamino)-pyrimidones useful as his 2-(3-amino-5-halo-2-pyridylalkylamino)-pyrimidones useful as his

1984-07-11

1987-05-12

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544320, 546256, A61K 31505, C07D23936

Patent

active

046650784

ABSTRACT:
The invention describes 5-halo-3-amino-2-pyridyl derivatives which are useful as histamine H.sub.1 -antagonists. Particular compounds described are 2-[4-(5-bromo-3-aminopyrid-2-yl)butylamino]-5-(6-methylpyrid-3-ylmethyl)-4 -pyrimidone and 2-[4-(5-bromo-3-aminopyrid-2-yl)butylamino]-5-(N-oxopyrid-4-ylmethyl)-4-py rimidone.

REFERENCES:
patent: 4154834 (1979-05-01), Brown et al.
Sach, Chem. Abst. 101:171108Z, eq. EP 112142.
Sach, Chem. Abst. 101:191953Z eq. EP 107914.
Adger et al, Chem. Abst. 102:95545t eq. EP 122109.
Sach, Chem. 99:22483f, eq. EP 68833.
Derwent Abstract 05126K (EP 68,833 Jan. 5, 1983).
Derwent Abstract 05127K (EP 68,834 Jan. 5, 1983).
Derwent Abstract 84-122085 (EP 107,914 May 9, 1984) U.S. Ser. No. 537,457.
Derwent Abstract 84-160122 (EP 112,142 Jun. 26, 1984).
U.S. Ser. No. 559,520.

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