Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1985-09-26
1986-08-05
Trousof, Natalie
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
564226, 564247, 546204, 548353, 548569, 514325, 514398, 514399, 514428, 514631, 514632, 544294, A61K 31505, A61K 31155, C07D12300
Patent
active
046043969
ABSTRACT:
The invention relates to novel [(2,3,9,9a-tetrahydro-3-oxo-9a-substituted-1H-fluoren-yl)oxy]ethanimidamid es and [(2,3,9,9a-tetrahydro-3-oxo-9a-substituted-1H-fluoren-7-yl)oxy]ethanimidic acid hydrazides, their derivatives and their salts. The compounds are useful for the treatment and prevention of injury to the brain and of edema due to head trauma, stroke (particularly ischemic), arrested breathing, cardiac arrest, Reye's syndrome, cerebral thrombosis, cerebral embolism, cerebral hemorrhage, cerebral tumors, encephalomyelitis, spinal cord injury, hydrocephalus, post-operative brain injury trauma, edema due to cerebral infections, various brain concussions and elevated intracranial pressure.
REFERENCES:
patent: 4316043 (1982-02-01), Cragoe et al.
patent: 4317922 (1982-03-01), Cragoe et al.
patent: 4337354 (1982-06-01), Cragoe et al.
patent: 4356313 (1982-10-01), Cragoe et al.
patent: 4356314 (1982-10-01), Cragoe et al.
Cragoe, et al., J. Med. Chem., "Agents for the Treatment of Brain Injury," 25: 567-579 (1982).
Cragoe, Jr. Edward J.
Woltersdorf, Jr. Otto W.
Caruso Charles M.
Hendriksen L.
Merck & Co. , Inc.
Pfeiffer Hesna J.
Szura Daniel T.
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