2,3,6,7-Tetrahydrothiazolo[3,2-a]pyrimidine derivatives having a

Details 2,3,6,7-Tetrahydrothiazolo[3,2-a]pyrimidine derivatives having a 2,3,6,7-Tetrahydrothiazolo[3,2-a]pyrimidine derivatives having a

1981-07-22

1983-12-06

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544278, 544231, A61K 31505

Patent

active

044193564

ABSTRACT:
Thiazolo[3,2-a]pyrimidine derivative of the formula: ##STR1## wherein R represents phenyl, alkyl of 1 through 4 carbon atoms, alkyl of 1 through 4 carbon atoms substituted by 1 through 3 halogen atom, alkenyl of 2 through 4 carbon atoms, or cycloalkyl of 3 through 6 carbon atoms and R.sub.1 represents hydrogen, or R and R.sub.1 each represent phenyl or unsubstituted alkyl of 1 through 4 carbon atoms, or R and R.sub.1 together represent an alkylene radical of 4 or 5 carbon atoms, and R.sub.2 and R.sub.3 each represent hydrogen or unsubstituted alkyl of 1 through 4 carbon atoms, or R and R.sub.1 each represent hydrogen, and one of R.sub.2 and R.sub.3 represents hydrogen and the other represents unsubstituted alkyl of 1 through 4 carbon atoms, or R.sub.2 and R.sub.3 both represent unsubstituted alkyl of 1 through 4 carbon atoms, are new compounds possessing pharmacological properties. They are especially useful in the treatment of rheumatic disease or allergic states, or as analgesics. Processes for the preparation of the compounds are described.

REFERENCES:
patent: 3888983 (1975-06-01), Baetz
patent: 4219649 (1980-08-01), Knoll et al.
Gabriel, S., Chem. Ber., 22, 1141, (1889).
Gabriel, S., Chem. Ber., 50, 804, (1917).
Gemmell et al., Agents et Actions, 9, 107, (1979).
Dieppe et al., Agents et Actions, 6, 618, (1976).

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