2,3,5-trisubstituted pyridines as inhibitors of cyclooxygenase-2

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514247, 514350, 514351, 514344, 514352, 514355, 514357, 546296, 546297, 546298, 546301, 546302, 546309, 546312, 546339, A61K21322, C07D 3144

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active

060462175

ABSTRACT:
The invention encompasses the novel compound of Formula I as well as a method of treating cyclooxygenase-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.

REFERENCES:
patent: 5480568 (1996-01-01), Pawloski et al.
patent: 5593994 (1997-01-01), Batt et al.
patent: 5686470 (1997-11-01), Weier
patent: 5861419 (1999-01-01), Dube et al.

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