2-(3,5-dialkyl-4-hydroxyphenyl)indole derivatives

Details 2-(3,5-dialkyl-4-hydroxyphenyl)indole derivatives 2-(3,5-dialkyl-4-hydroxyphenyl)indole derivatives

1985-08-29

1987-09-22

Ceperley, Mary E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548511, A61K 3140, C07D20912

Patent

active

046955810

ABSTRACT:
A compound represented by the formula ##STR1## wherein R.sub.1 represents a lower alkyl group; each of R.sub.2 and R.sub.3 represents an alkyl group having 1 to 3 carbon atoms; and each of R.sub.4, R.sub.5 and R.sub.6 represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group, a lower alkanoyloxy group, an aralkyloxy group, a lower alkylthio group, a lower haloalkyl group, a hydroxyl group, a cyano group, a nitro group, an amino group, a mono- or di-(lower alkyl or aralkyl)amino group or a group of the formula ##STR2## in which R.sub.7 represents a lower alkylene group having at least 2 carbon atoms, one of R.sub.8 and R.sub.9 represents a hydrogen atom or a lower alkyl group and the other represents a lower alkyl group, and R.sub.10 represents a hydrogen atom or a lower alkyl group; or any two of R.sub.4, R.sub.5 and R.sub.6 which are adjacent to each other, together, represent a lower alkylenedioxy group, and a salt thereof; and a process for production thereof. This compound has 5-lipoxygenase inhibiting activity and is useful as a medicament.

REFERENCES:
patent: 4024155 (1977-05-01), Pigerol et al.
patent: 4543360 (1985-09-01), von Angerer et al.
Yasuo Isomura et al., Chem. Pharm. Bull., 31(9)3168-3178 (1983).

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