2-, 3-, 5-, 8-, 10- and/or 11-substituted dibenzoxazepine compou

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

540547, A61K 3155, C07D26720, C07D28116

Patent

active

053247221

ABSTRACT:
The present invention provides substituted dibenzoxazepine compounds of Formula I: ##STR1## which are useful as analgesic agents for the treatment of pain, pharmaceutical compositions comprising a therapeutically-effective amount of a compound of Formula I in combination with a pharmaceutically-acceptable carrier, and a method for eliminating or ameliorating pain in an animal comprising administering a therapeutically-effective amount of a compound of Formula I to the animal.

REFERENCES:
patent: 3534019 (1970-10-01), Coyne et al.
patent: 3624104 (1971-11-01), Cusic et al.
patent: 3917649 (1975-11-01), Mueller
patent: 3989719 (1976-11-01), Mueller
patent: 3992375 (1976-11-01), Mueller
patent: 4045442 (1977-08-01), Mueller
patent: 4125532 (1978-11-01), Mueller
patent: 4170593 (1979-10-01), Mueller
patent: 4559336 (1985-12-01), Mueller
patent: 4559337 (1985-12-01), Mueller
patent: 4614617 (1986-09-01), Mueller
patent: 4728735 (1988-03-01), Belanger et al.
Tilek et al, Chemical Abstract vol. 62, No. 14707g (1964).
Geigy, J. R., Chem. Abstract vol. 66, No. 78117a (1966).
Drower, et al., "The Antiociceptive Effects of Prostaglandin Antagonists in the Rat," European Journal of Pharmacology, 133, 249-256 (1987).
J. H. Sanner, "Dibenzoxazepine Hydrazides as Prostaglandin Antagonists," Intra-Science Chem. Rept., vol. 6, No. 1, 1-9 (1972).
K. Nagarajan, et al., "Synthesis of 10,11-Dihydrodibenz[b,f][1,4]oxazepine Derivatives as Potential Anticonvulsants & Psychotropic Agents," Indian Journal of Chemistry, vol. 24B, 840-844 (1985).
D. E. MacIntyre, et al., "Antagonism of Human Platelet Responses to Stimulatory and Inhibitory Prostaglandins," Prog. Lipid. Res. 20 (1-4), 453-9 (1981).
R. Gimet, et al., "Quantitative Determination of Polymorphic Forms in a Formulation Matrix Using the Near Infra-Red Reflectance Analysis Technique," J. Pharmaceutical & Biomedical Analysis, vol. 5, No. 3, 205-211 (1987).
J. H. Sanner, et al., "Structure-Activity Relationships of some Dibenzoxazepine Derivatives as Prostaglandin Antagonists," Advances in the Biosciences, 9, 139-148 (1972).
A. Rakovska, et al., "Antagonistic Effect of SC-19220 on the Responses of Guinea-Pig Gastric Muscles to Prostaglandins E1, E2 and F2," Arch. Int. Pharmacodyn., 268, 59-69 (1984).
W. E. Coyne, et al., "Anticonvulsant Semicarbazides," J. Med. Chem., 11(6), 1158-1160 (1968).
K. Gyires, et al., "The Use of the Writhing Test in Mice for Screening Different Types of Analgesics," Arch. Int. Pharmacodyn., 267, 131-140 (1984).
A. Bennett, et al., "Antagonism of Prostanoid-Induced Contractions of Rat Gastric Fundus Muscle by SC-19220, Sodium Meclofenamate, Indomethacin or Trimethoquinol," Br. J. Pharmac., 71, 169-175 (1980).
C. A. Maggi, et al., "The Effect of SC-19220, a Prostaglandin Antagonist, on the Micturition Reflex in Rats," European Journal of Pharmacology, 152, 273-279 (1988).
George, et al., "Antagonism of Alcohol Hypnosis by Blockade of Prostaglandin Synthesis and Activity: Genotype and Time Course Effects," Pharmacology Biochemistry & Behavior, vol. 19, 131-136 (1983).
S. Nakajyo, et al., "Inhibitory Effect of Bassianolide, A Cyclodepsipeptide, on Drug-Induced Contractions of Isolates Smooth Muscle Preparations," Japan. J. Pharmacol., 32, 55-64 (1982).
A. Gomes, et al., "Pharmacodynamics Venom of the Centipede Scolopendra subspinipes dehaani,"Indian Journal of Experimental Biology, vol. 20, 615-618 (1982).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

2-, 3-, 5-, 8-, 10- and/or 11-substituted dibenzoxazepine compou does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 2-, 3-, 5-, 8-, 10- and/or 11-substituted dibenzoxazepine compou, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 2-, 3-, 5-, 8-, 10- and/or 11-substituted dibenzoxazepine compou will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2377579

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.