2,3,5,6-Tetracarboxy-1,4-dihydropyridine derivatives

Details 2,3,5,6-Tetracarboxy-1,4-dihydropyridine derivatives 2,3,5,6-Tetracarboxy-1,4-dihydropyridine derivatives

1974-11-15

1976-03-09

Rotman, Alan L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2602948F, 2602948G, 2602949, 2602955B, 424266, C07D21355

Patent

active

039431401

ABSTRACT:
1,4-Dihydropyridines bearing carboxy functions in the 3-, 5- and 6- or 2-, 3-, 5- and 6-positions and being substituted in the 4-position by phenyl, substituted phenyl, naphthyl, phenylalkyl or a heterocyclic group are antihypertensive agents and coronary vessel dilators. The compounds, of which 2-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5,6-tricarboxylic acid triethylester is a representative embodiment, are prepared through condensation of an enamine with an ylidene acid ester, the latter being separately prepared or prepared in situ.

REFERENCES:
patent: 3855231 (1974-12-01), Meyer et al.
patent: 3860601 (1975-01-01), Meyer et al.
patent: 3862161 (1975-01-01), Bossert et al.

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