Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1986-03-07
1988-01-12
Daus, Donald G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514227, 514254, 514292, 544120, 544126, 544295, 544361, 544363, 544364, 544405, 544406, 546 84, 546 85, 546 87, A61K 31495, C07D47106
Patent
active
047192119
ABSTRACT:
This invention concerns tetrahydropyridoindoles of the formula: ##STR1## wherein Q represents ##STR2## in which R.sub.3 is hydrogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, or --COO(C.sub.1-2) alkyl, and n is an integer from 1 to 7; R.sub.1 is hydrogen, halogen, hydroxy, or C.sub.1-3 alkyl; and R.sub.2 is hydrogen, C.sub.1-4 alkyl or --(CH.sub.2).sub.m --A where A is --N(CH.sub.3).sub.2,--N(C.sub.2 H.sub.5).sub.2, ##STR3## in which Ar is 2-pyrimidinyl, 2-pyrazinyl, phenyl, or phenyl substituted by a methyl, ethyl, methoxy, ethoxy, or trifluoromethyl group; and m is an integer from 1-4, or physiologically acceptable salts thereof, providing however that when n is 1, Q may not be quinolinyl. These compounds exhibit antihypertensive properties. Four of the disclosed compounds also exhibit antipsychotic properties.
Also disclosed are compounds of Formula XX in which Q of Formula I is replaced by Q.sub.1, wherein Q.sub.1 is 2- or 3-pyridinyl, and R.sub.2 of Formula I is restricted to hydrogen. The compounds of Formula XX exhibit antipsychotic properties.
REFERENCES:
patent: 4272539 (1981-06-01), Koletar et al.
patent: 4361566 (1982-11-01), Van Dyke, Jr. et al.
patent: 4431649 (1984-02-01), Welch et al.
patent: 4663456 (1987-05-01), Abou-Gharbia
Derwent Abstract No. 14,306F of Japanese Kokai No. 22853, published Oct. 14, 1964, to Fujisawa Pharm. Co., Ltd.
Abou-Gharbia Magid A.
Freed Meier E.
American Home Products Corporation
Daus Donald G.
Seifert Arthur G.
Shen Cecilia
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