2,3,4,5-tetrahydro-1-benzoxepins, the use thereof and pharmaceut

Details 2,3,4,5-tetrahydro-1-benzoxepins, the use thereof and pharmaceut 2,3,4,5-tetrahydro-1-benzoxepins, the use thereof and pharmaceut

1990-10-31

1993-03-16

Fan, Jane T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514422, 546269, 548525, A61K 3144, C07D40504

Patent

active

051944421

ABSTRACT:
2,3,4,5-Tetrahydro-1-benzoxepins of the formula I ##STR1## with R.sup.1 equaling, inter alia, H, alkyl, alkoxy, Hal, alkylsulfonyl, arylsulfonyl, R.sup.2 equaling H, alkyl, alkoxy, OH, R.sup.3 to R.sup.6 H or alkyl and X equaling ##STR2## have excellent efficacy as antihypertensives, as coronary therapeutics, as agents for the treatment of cardiac insufficiency, of disturbances of cerebral and peripheral blood flow or of disturbances of intestinal motility, premature labor, obstructions of the airways or of the urinary tract or of the biliary tract or as spasmolytics.

REFERENCES:
patent: 4446113 (1984-05-01), Evans et al.
patent: 4555509 (1985-11-01), Evans et al.
Goodman and Gilman's The Pharmacological Basis of Therapeutics pp. 191, 623, 785, 926.

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