Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1993-09-03
1994-06-07
Ramsuer, Robert W.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514323, 514411, 544142, 546200, 548428, A61K 3140, A61K 31535, C07D20956, C07D41306
Patent
active
053189671
ABSTRACT:
The invention relates to cis-2,3,3a,4,5,9b-Hexahydro-1H-benzo[b]indole derivatives of the formula ##STR1## wherein R.sup.1 is a residue of the formula --O--CO--NR.sup.4 R.sup.5, R.sup.2 is lower alkyl, lower cycloalkyl or lower alkyl substituted by lower cycloalkyl, aryl, aroyl, aroylamino, amino or by a cyclic amino, amide or imide group, R.sup.3 is hydrogen or lower alkyl, R.sup.4 is lower alkyl and R.sup.5 is hydrogen or lower alkyl,
the corresponding trans isomers or cis-trans isomeric mixtures and pharmaceutically acceptable salts thereof. These compounds and salts are especially suitable for the treatment or prophylaxis of cognitive disorders and senile dementia particularly, Alzheimer's disease, and for the improvement of memory capacity.
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Weber et al. Proc. Natl. Acad. Sci. USA 83, 1986, 8784.
Watson et al. Pharmacol. Exp. Ther. 237 (1986) 419.
Eberlein et al. Trends Pharmacol. Science 10 (1989) 50.
Kilbinger et al. Eur. J. Pharmacol. 103 (1984) 313.
J. Pharm. Pharmacol 1991, 43:11-16.
Chim.Ther.-Recherches dans la serie des aryl-3 pyrrolidines III. Preparation de derives du benzo(e) indole et de l'indano(1,2b)pyrrole 450-458 (1972).
Bruderer Hans
Godel Thierry
Imhof Rene
Jakob-Roetne Roland
Gould George M.
Hoffmann-La Roche Inc.
Isgro William G.
Ramsuer Robert W.
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