2-[2-Thiazolyl or 2-guanidino-4-thiazolyl methylthioethyl(or but

Details 2-[2-Thiazolyl or 2-guanidino-4-thiazolyl methylthioethyl(or but 2-[2-Thiazolyl or 2-guanidino-4-thiazolyl methylthioethyl(or but

1982-04-05

1984-03-27

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

546261, 546263, 546280, 546193, 546281, 544126, C07D41712, A61K 3144

Patent

active

044394373

ABSTRACT:
This invention relates to 2-amino-3-hydroxy, and 3-carboxy pyridine derivatives, in which the amino group is substituted by a methylthioethyl, butyl or oxypropyl group bearing a terminal heterocyclic group. The compounds have histamine H.sub.2 -antagonist activity. A specific compound of this invention is 2-[2-(2-guanidino-4-thiazolylmethylthio)ethyl]amino pyridine 3-carboxylic acid.

REFERENCES:
patent: 3932644 (1976-01-01), Durant et al.
patent: 4218452 (1980-08-01), Brown et al.
patent: 4234588 (1980-11-01), Brown et al.
patent: 4307104 (1981-12-01), Roantree et al.
Derwent Abstract 38240C (WP 8000966), May 15, 1980.
Derwent Abstract 64650C (EP 15138), Sep. 3, 1980.

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