2{[2-(substituted amino)ethyl]sulfonyl}ethyl...

Details 2{[2-(substituted amino)ethyl]sulfonyl}ethyl... 2{[2-(substituted amino)ethyl]sulfonyl}ethyl...

2006-11-29

2010-02-02

Desai, Rita J (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C548S413000, C514S277000, C514S076000

Reexamination Certificate

active

07655799

ABSTRACT:
2-{[2-(Substituted amino)ethyl]sulfonyl}ethyl N,N,N′,N′-tetrakis(2-chloroethyl)-phosphorodiamidates, their preparation and intermediates in their preparation, pharmaceutical compositions containing them, and methods of treatment using them. The compounds are useful for treating cancer, alone and in combination with other anticancer therapies.

REFERENCES:
patent: 5556942 (1996-09-01), Kauvar et al.
patent: 6506739 (2003-01-01), Herr et al.
patent: 2005/0267075 (2005-12-01), Allen et al.
patent: WO 95/09866 (1995-04-01), None
patent: WO 01/83496 (2001-11-01), None
patent: WO 2005/118601 (2005-12-01), None
U.S. Appl. No. 60/588,436, filed Dec. 1, 2005, Allen et al.
Morgan AS et al., “Tumor Efficacy and Bone Marrow-sparing Properties of TER286, a Cytotoxin Activated by Glutathione S-Transferase”,Cancer Res., v.58, pp. 2568-2575, Jun. 15, 1998.
Rosario LA, et al., “Cellular Response to a Glutathione S-Transferase P1-1 Activated Prodrug”,Mol. Pharmacol., v. 58, pp. 167-174, Jul. 2000.
Jain M et al., “Sulfonyl-containing aldophosphamide analogues as novel anticancer prodrugs targeted against cyclophosphamide-resistant tumor cell lines”,J. Med. Chem., v.47, pp. 3843-3852, Jul. 15, 2004 (published on Web Jun. 17, 2004).
TEW K.D. “TLK-286: A novel glutathione S-transferase-activated prodrug”. Expert Opinion on Investigational Drugs, Ashley Publications Ltd., London, GB, vol. 14, No. 8, 2005, pp. 1047-1054.

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