Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1985-06-05
1987-03-03
Hollrah, Glennon H.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514313, 544284, 544293, 546162, 546193, 546284, 546321, 546322, A61K 31505, A61K 3147, C07D40112, C07D40114
Patent
active
046475656
ABSTRACT:
Dihydropyridines of the formulae ##STR1## wherein R is chlorothienyl or mono- or disubstituted phenyl where said substituent is fluoro, chloro, bromo or trifluoromethyl; R.sup.1 and R.sup.2 are each alykl; R.sup.3 and R.sup.4 when taken separately are each hydrogen or alkyl; R.sup.3 and R.sup.4 when taken together with the nitrogen to which they are attached are piperidine or pyrrolidine; R.sup.5 is alkyl or 2-hydroxyethyl; R.sup.6 is hydrogen or methoxy; X and Z are each hydrogen or methoxy; Y is alkylene; R.sup.7 is chlorophenyl or trifluoromethyl-chlorophenyl; p is 0 or 1; and Q is CH or N are useful in the treatment of hypertension, heart failure and angina.
REFERENCES:
patent: 4341893 (1982-07-01), Manoury
Arrowsmith John E.
Campbell Simon F.
Cross Peter E.
Dickinson Roger P.
Frost Albert E.
Hollrah Glennon H.
Knuth Charles J.
McManus James M.
Pfizer Inc.
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